Dr. Joe’s Nitric Oxide Support is a unique formula designed to maintain healthy blood pressure levels by enhancing nitric oxide synthesis. 120 count per bottle. The aging process, an over consumption of high glycemic load foods, stress, physical inactivity and toxic burden can all wreak havoc on endothelial cells by disrupting inflammatory balance. This disruption can lead to arterial rigidity and vasoconstriction, due to the decrease in levels of circulating nitric oxide (NO), a potent vasodilator and cell signaling molecule. NO is produced with the help of endothelial nitric oxide synthase (eNOS) during the recycling of L-arginine to L-citrulline in the urea cycle. NO diffuses into the smooth muscle cells lining arteries and initiates a cascade of phosphorylation reactions resulting in smooth muscle relaxation and vasodilation of the artery. Using a combination of high-dose L-citrulline, quercetin, and grape see extract, Dr. Joe’s Nitric Oxide Support delivers full-spectrum support to help maintain inflammatory balance, arterial elasticity, optimal nitric oxide levels and blood flow. Recent research shows that when compared to L-arginine, supplemental L-citrulline maintains peak plasma NO levels for twice the length of time, resulting in normal blood flow. Quercetin is a well-known flavonoid shown to inhibit ICAM-1 and NFkB, allowing for a normal inflammatory balance.