Home | Products | Nitric Oxide Support Nitric Oxide Support Rated 5.00 out of 5 based on 4 customer ratings 4 Reviews Dr. Joe’s Nitric Oxide Support is a unique formula designed to maintain healthy blood pressure levels by enhancing nitric oxide synthesis. It provides multidimensional support for optimal blood pressure, helps maintain endothelial cell elasticity, helps preserve coronary arteries, and enhances circulation nitric oxide levels. Purchase options: One-Time Subscribe Save 5% Cancel when you want to Easily cancel with no fees required Edit your subscription anytime Control quantity, order, and payment details $53.99 $51.29 /month Deliver:Every month for $51.29 (5% off)Every 2 months for $48.59 (10% off)Every 3 months for $48.59 (10% off)Every 4 months for $48.59 (10% off) one time $51.29 / month — save 5% $48.59 every 2 months — save 10% $48.59 every 3 months — save 10% $48.59 every 4 months — save 10% Free shipping for any order over $49.99 within the Continental US. Nitric Oxide Support quantity ﹣ ﹢ Add to cart Refer to a Friend Login or Create an Account to get a referral link. Best Seller Best Seller ABOUT Dr. Joe’s Nitric Oxide Support is a unique formula designed to maintain healthy blood pressure levels by enhancing nitric oxide synthesis. 120 count per bottle. The aging process, over-consumption of high glycemic load foods, stress, physical inactivity, and toxic burden can all wreak havoc on endothelial cells by disrupting the inflammatory balance. This disruption can lead to arterial rigidity and vasoconstriction, due to the decrease in levels of circulating nitric oxide (NO), a potent vasodilator and cell signaling molecule. NO is produced with the help of endothelial nitric oxide synthase (eNOS) during the recycling of L-arginine to L-citrulline in the urea cycle. NO diffuses into the smooth muscle cells lining arteries and initiates a cascade of phosphorylation reactions resulting in smooth muscle relaxation and vasodilation of the artery. Using a combination of high-dose L-citrulline, quercetin, and grape seed extract, Dr. Joe’s Nitric Oxide Support delivers full-spectrum support to help maintain inflammatory balance, arterial elasticity, optimal nitric oxide levels, and blood flow. Recent research shows that when compared to L-arginine, supplemental L-citrulline maintains peak plasma NO levels for twice the length of time, resulting in normal blood flow. Quercetin is a well-known flavonoid shown to inhibit ICAM-1 and NFkB, allowing for a normal inflammatory balance. NOTE If you have low blood pressure, speak with us before taking this product. We may recommend a smaller serving or additional supplements. This product should not be taken the same day with medication used to treat erectile dysfunction. SUGGESTED USE 120 count per bottle. 4 capsules per day or as recommended by your health care professional. If this is your first time taking this supplement, Dr. Joe recommends starting off with 1 capsule. See how you feel, and increase as necessary. Some individuals have reported a dramatic increase in energy when taking this supplement. If that is true in your case, it is recommended that you take this supplement early in the day. INGREDIENT BENEFITS L-Citrulline L-citrulline is one of three dietary amino acids in the urea cycle responsible for converting ammonia into urea as well as for the production of NO, an important cellular signaling molecule. In this process, L-citrulline is the natural precursor of L-arginine, the substrate used by endothelial nitric oxide synthase (eNOS) to produce NO. Quercetin Dihydrate A flavonoid found in a variety of botanicals, vegetables, and fruits, quercetin is a potent antioxidant that inhibits inducible ICAM-1 expression, an important pathway for maintaining normal inflammatory balance. MegaNatural® BP Grape Seed Extract MegaNatural® BP is a premium grape seed extract made in California from a special seed blend extracted with water from a variety of white wine grape seeds. Grapes and grape products contain phenolic compounds found to have health-promoting properties, particularly in cardiovascular wellness. Signs and Symptoms of Deficiencies Symptoms of deficiency may include: Fatigue Low workout potential Less stamina Erectile dysfunction or decreased libido Poor memory Irritability, depression or anxiety Insomnia High blood pressure (hypertension) Decreased heart function Asthma or poor lung function Thin bones