1. Selenium
Selenium is an essential trace mineral — the body cannot produce it, so it must be obtained from diet or supplementation.
- Supports antioxidant defenses by helping form antioxidant enzymes that prevent cell damage.
- Thyroid and immune support: plays a key role in protecting cells and promoting proper thyroid hormone conversion.
- Involved in reproductive, metabolic, and DNA synthesis processes through selenoprotein activity.
- Some evidence links adequate selenium with reduced risk of certain cancers, better cardiovascular outcomes, and lower all-cause mortality (though findings vary).
2. Broccoli Sprout Extract / Sulforaphane
Broccoli sprouts are highly concentrated in glucoraphanin, which converts into sulforaphane — a powerful bioactive compound.
- Anti-inflammatory and antioxidant effects: supports cellular defense and protects tissues from oxidative stress.
- Detoxification support: activates Phase II detox enzymes via the NRF2 pathway.
- Liver health: glucoraphanin supplementation improved ALT biomarkers in middle-aged adults.
- Glucose metabolism: sulforaphane has been shown to reduce fasting blood glucose in individuals with elevated levels.
- Gut & inflammation support: broccoli sprouts may improve gut microbiome balance and reduce inflammatory markers.
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3. Combined Rationale
Pairing an antioxidant mineral (selenium) with a phytochemical extract (broccoli sprout/sulforaphane) provides complementary cellular protection and metabolic support.
- Selenium strengthens the body’s antioxidant enzyme systems via selenoproteins.
- Sulforaphane activates detoxification pathways, boosts antioxidant defenses, and regulates inflammatory responses.
- Together, they support:
- Protection against oxidative stress
- Enhanced detoxification & clearance of harmful metabolites
- Reduced inflammation
- Improved metabolic function and gut health
- Overall cellular resilience and immune balance
This synergy may be especially relevant in nutritional programs focused on recovery, oxidative-stress management, or neuroprotection (e.g., TBI-related nutrition considerations).
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